It is one of the major tuberculin skin tests used around the world, largely replacing multiple-puncture tests such as the tine test. The Heaf test, tuberculin skin test pdf form of tine test, was used until 2005 in the UK, when it was replaced by the Mantoux test.
The Mantoux test is endorsed by the American Thoracic Society and Centers for Disease Control and Prevention. It was also used in the USSR and is now prevalent in most of the post-Soviet states. Tuberculin is a glycerol extract of the tubercle bacillus. The tuberculin reaction was first described by Robert Koch in 1890.