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Electrical and chemical activity regulating this phase seems to originate in the brain stem and is characterized most notably by an abundance of the...

Electrical and chemical activity regulating this phase seems to originate in the brain stem and is characterized most notably by an abundance of the neurotransmitter acetylcholine, combined with the 8 hour sleep paradox pdf nearly complete absence of monoamine neurotransmitters histamine, serotonin, and norepinephrine. REM and non-REM sleep alternate within one sleep cycle, which lasts about 90 minutes in adult humans.


As sleep cycles continue, they shift towards a higher proportion of REM sleep. The transition to REM sleep brings marked physical changes, beginning with electrical bursts called PGO waves originating in the brain stem.

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